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2007 № 4
Review
Martynov A.V.,
Smelyanskaya M.V., Peremot S.D.
NEW
APPROACH TO DESIGN AND SYNTHESIS OF THERAPEUTIC AND PREVENTIVE DRUGS,
TAKING INTO ACCOUNT INTERSPECIES POLYMORPHISM OF RECEPTORS (METHOD OF
PRECISION PARTIAL MODIFICATION)
In English
In the article are
presented new theory of drug’s development with used of unclear and
selfassembled structures – partial modified biopolymers. Also was shown
perspectives in gene therapy developments and new design of actual
vaccines with used principle of unclear structures .
Romanova E.A., Popov N.N.
IMMUNOREGULATING POSSIBILITIES OF LYMPHOID AND MIELOID CELLS
In Russian
The basic
immunological aspects of hemopoietic and lymphoid cell transplantation
in therapeutic and oncologic practice are outlined. Possibilities of
their separate and joint application come into question with a
regeneration and corrective purpose as facilities with powerful
polyregulating potential.
Experimental
works
Babych E.M., Kalinichenko S.V.,
Ryzhkova T.A.
THE
CHANGES OF THE BIOLOGICAL PROPERTIES OF E.COLI, K.PNEUMONIAE AND
AERUGINOSAE FALLING UNDER INFLUENCE OF C.DIPHTHERIAE EXOTOXIN
In Ukrainian
Influence of
different doses of diphtheria exotoxin on growth kinetic, antibiotic
resistance, adhesive and anticomplementary activity of gram-negative
bacteria was studied. It was determined that adhesive activity didn’t
change but anticomplementary activity was 1,26-1,52 times less. Growth
kinetic of gram-negative bacteria increased for certain in 1,7-2,8 times
(p<0,05) after 0,1 ml of diphtheria toxin had been added in 1,0 ml of
the nutrient medium; influence of lager dose of exotoxin (0,3 ml of
exotoxin in 1,0 of the nutrient medium) resulted to growth kinetic
depression in 2,0-3,4 times (p<0,05). Antibiotic sensibility decreased
on average in 1,2-1,4 times independently of the exotoxin dose.
Popov N.N. , Savchenko A.V. ,
Romanova E.A.
IVIG-therapy
INFLUENCE TO THE IMMUNOPATOGINETIC factors epiglottis necrosis
In Russian
The influence of
IVIG-therapy for clinical course of disease and immune indicators 23
patients with necrosis form acute epiglottitis was searched. It was
determined that this therapy renders clinically important effect and
positive influence for immune processes, which play famous pathogenetic
part in the development of epiglottis necrosis. By influence of IVIG-therapy
the producing activity of proinflammatory agent descends, the content of
micro- and middle molecular circular immune complexes, collagen and
elastin autoantibodyes reduces.
Batrak E. A., Chuprinova S.I., Zavada N. P.,
Rjabova I.S.
USE OF GROWTH FACTORS OF MICROORGANISMS FOR
ESCALATING A BIOMASS
In Ukrainian
Influence of growth factors of microorganisms (enhancers) on occurrence
of the first colonies and on increase in a biomass of microbic cells is
studied. It is
investigated,that
increase qualities of microorganisms considerably increase on nutrient
mediums with addition enhancers in comparison with standards medium.
Concentration
enhancers slightly Influences speed of increase in a form make colony of
microorganisms for the certain interval of time.
Kazmirchuk V.V., Bilocon
I.F., Evsukova V.Y., Shulga N.N., Povolokina I. V., Yhimenko V.I.,
Volyanska N.A., Radchenko E.A.
WORKING
COMPOSITIONS
ANTIMICROBIAL TOOL WITH SPECIFIC SUPERACTIVITY
In Russian
The optimal antimicrobial combined compositions for treatment of
contagion’s microbial aetiology were developed, the structure of
auxiliary materials influencing rising of specific action of awake
components picks up.
Suhanova L.
A.
IMMUNOLOGICAL REACTIVITY OF THE
PATIENTS UNDERGONE THE SURGERY FOR PULMONARY TUBERCULOSIS
DEPENDING ON THE STATE OF CONNECTIVE TISSUE
In Russian
The carried stady of the connective tissue state in 50 patients
undergone the pulmonary tuberculosis revealed that more than a half
(58%) demonstrated the signs of connective tissue dysplasia (CTD) of
lungs and of all organism. All observed patients got the pre- and
postoperative changes in immunological reactivity that is in conformity
with the literature data. Nevertheless, the patients with pulmonary TB
with x-ray and phenotype signs of CTD (compared to the individuals with
absent CTD signs) demonstrated the more T-lymphocytes number that is an
evidence of the strained cellular immunity as well as the higher level
of the pulmonary and bronchial antigene, complement consumption before
and after surgery and bronchial antigen complement consuption after
operationthat reflects the humoral immune activity. The pulmonary CTD
does not influence eesentially on the immunological reactivity of the
organism.
History of medicine
Bobbin I.V., Bobin V.V.
VLADIMIR PAVLOVICH BOBIN IS PROMINENT
UKRAINIAN DOCTOR, PUBLICMAN OF KHARKOV MEDICAL SOCIETY
In Russian
In memory of Vladimir Pavlovich Bobin - prominent Ukrainian doctor,
publicman of Kharkov medical society. Historical review. |
