|
Scientific Journal "Annalls of Mechnicov's Institute" |
|||
|
|
|
2006 № 1
Reviews
Hernaya T.V.
In Ukrainian
Yelyseyeva I., Babich Ye., Volyansky Yu.,
Sklyar N., Bilozersky V.I.
A ROLE OF
LATENT, DIFFICULTLY CULTIVATED OR NON-CULTIVATED PERSISTENT BACTERIA IN
HUMAN PATHOLOGY
Krestetska S.L., Krestetsky M.G., Voliansky A.U., Koliada O.N., Kazmirchuk V.V. In Ukrainian LATENT INFECTION AS A RISK FACTOR FOR ATHEROSCLEROSIS FAST PROGRESSION
A decade ago, the correction of
hypercholesterolemia and hypertension was expected to prevent the fast
progressing of atherosclerotic process and, in an essential measure, to
warn occurrence of critical vascular events. But now, аn increasing body
of evidence suggests that existing conventional risk factors such as
hypertension, hyperlipidemia, diabetes mellitus and smoking account for
only about 50% of atherosclerosis clinical occurrence. This fact proves
expediency of new search for reliable influence factors and estimation
its risks value. The infectious hypothesis proposes that various
microorganisms may serve as potential etiological factors, linking
inflammation and atherosclerosis (or its clinical manifestations, which
now is the leading cause of critical vascular events). Evidence from
seroepidemiology, molecular biology, immunology, pathology, animal
models and human antibiotic intervention studies, collectively have
suggested a largely positive association between infection and
atherosclerosis. However, the precise nature of a causal or coincidental
link between infection and atherosclerosis remains to be determined. A
current perspective is presented in this review. Experimental research
Pozdnyakov S.V., Lebedyuk M.N., Fuchigy I.S., Slavina N.G., Popova J.A., Margolin O.N. In Ukrainian
SENTINEL
SURVEILLANCE ON HIV-INFECTION IN PATIENTS WITH SEXUALLY TRANSMITTED
DISEASES (STD). EVALUATION OF THE DISTRIBUTION
Pozdnyakov S.V., Lebedyuk M.N., Fuchigy I.S., Slavina N.G., Popova J.A., Margolin O.N. In Ukrainian Evaluation of the behavioral risk models influencing HIV-infection distribution, subjective and objective consideration to the risk group and level of the AIDS issues information were done in the frames of the sentinel surveillance control (SSC). For the processing and evaluation of the respondent’s anonymous polling data, personal computer program was used. It was marked significant part of the STDs patients which are at the risk zone, including drug abuse. At the same time, level of the complex AIDS issues conversance is low, wile subjective opinion value added. Disbelief in possible turn for the safe behavior in 40% of polled shows potential threat of the STDs patients for the further infection distribution in the marked group and ordinary population through the sexual contacts. Use of the effective informational and educational programs for the patients with STDs is needed as well as constant SSC for the control of the situation.
Martynov A.V., Klemchuk L.V., Osolodchenko T.P.,
Batrak E.A., In Ukrainian In the paper, results of studies on antimicrobial and antifungal properties of succinylated β-cyclodextrin and its inclusion complex with nystatin are presented. It is shown that β-cyclodextrin does not form inclusion complex with nystatin whereas succinylated β-cyclodextrin forms opalescent inclusion complex with nystatin. Mass of the inclusion complex determined by gel-electrophoresis differs considerably from the calculated one. It may be caused by the more rigid structure of inclusion complex and correspondingly by decrease of its mobility in the gel. It is shown that succinyl β-cyclodextrin has apparent activity against P.aeruginosa, C.albicans and A.niger and strong one against S.aureus whereas in accordance with literature non-acylated β-cyclodextrin has no antimicrobial and antifungal properties. Inclusion complexes between succinyl β-cyclodextrin and nystatin were more active (by 15%-30%) compared to nystatin and β-cyclodextrin taken separately.
History of Science Pugach N.B. |
|