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Immunorehabilitation Laboratory
Current project: "Acylated derivatives of proteins and polysaccharides from P. Aeruginosa antigens, development vaccines on its basis"
Main research area: 1) Study of immune system dysfunction: - analysis and study of the role of bacterial and viral associations in the etiology and pathogenesis of cancer diseases; and the ground of the tactics of the complex clinical-laboratory diagnosis and the treatment of the patients with cancer (antiviral drugs for cancer treatment); - analysis and study of role of intracellular infectious agents (viruses, mycoplasmas, chlamydias and their associates) in dysfunction of immune system; - study of phenomenon of intracellular infectious agents stealth persistence in immune system cells and its role in some chronic diseases etiology and pathogenesis 2) In area of preventive and medical drugs development: - drug – design of antiviral, anticancer and immunopotentiating drugs based on neural-network technology and nonlinear logics soft; - development of the new generation of antimicrobial and antiviral vaccines with chemically modified antigens; - development new generation of biotechnological drugs with prolonged action (chemically modified interleukins, interferons, specific immunoglobulins and supramolecular complexes);
Staff: Chernyavky V.I., Head of laboratory, Ph.D., M.D., leader research worker
Romanova E. A.,
Ph.D.,
Biol.D., senior research worker
Sidorenko T.A., research worker
Igumnova
N.A., research worker Chernova L.V., laboratory assistant
1 Martynov A.V., Kislichenko V.S. Synthesis and properties of clathrate complexes between acylated immunoglobulins and low molecular weight substances // Pharm . J.-2004.- Vol. 2.- P.48-52 2 Martynov A.V., Smilanskaya M.V., Peremot S.D. Studying of viral adhesion inhibitor p-carbetoxy –N-phenylaconitimid on in vovo model // Drugs.-1999.- N 3-4.- P.79-81 (Ukr) 3 Martnov A.V., Smilanskaya M.V., Kuchma I.Yu., Peremot S.D. Antiviral activity of aconitic acid imides – new class of substances // News in pharmacy .- 1998.-Vol.2, N.18.-P.97-99 (Ukr) 4 Martynov A.V., Kislichenko V.S., Smilanskaya M.V., Peremot S.D., Sapoznicova N.F. Studying of Ribes nigrum some extracts in anticancer effect // Clinical Pharmacy.- 1998.-Vol.2, N 3.-P.89-91 5 Martynov A.V., Smilanskaya M.V., Peremot S.D. Studying of imides 2- and 3- carboxylic acid imides and albumines derivatives in antiviral effects // Drugs.- 2000.-N 6.-P.51-54 (Ukr) 6 Martynov A.V., Smilanskaya M.V., Peremot S.D. Antiviral effect of polyanionic albumin in C-2 therapeutic system // Drugs.- 2002.-N 1-2.-P.39-42 (Ukr) 7 Martynov A.V., Smilansaya M.V., Popova N.V., Kislichenko V.S., Kozuch I.O., Volkovich O.O., Tkachenko O.Yu. Studying vegetable proteoglycans and polysaccharides in therapeutic system C-2 on antiviral properties // Pharm. J.-2001.-N 4.-P.74-77 (Ukr) 8 Martynov A.V., Chernych V.P. High-molecular weigh drugs – biotechnology products- chemical modification as instrument of precise influence on its pharmacology properties // Clin. Pharmacy.- 2002.- Vol.6, N.3.-P.3-8 (Ukr) 9 Kovalev V.N., Martynov A.V., Krasnicova T.O., Stepanova S.I. Vegetable lectins as biological active substances for drugs development // Phys. Act.Subst.-2001.- N 1 (31).- P.74-78 (Ukr) 10 Chernych V.P., Martynov A.V. Synthesis and biological activity of acylated tannins // Phys. Act.Subst.-2001.- N 2 (32).- P.16-19 (Ukr) 11 Dikiy I.L., Martynov A.V. Differential – rethrotranspositional theory of cancerogenesis// News in Pharmacy.- 1997.- N 1(15).-P.88-93. (Ukr) 12 Schemchuk L.A., Chernych V.P., Martynov A.V. Synthesis of trans-aconitic acid imides // J. Org.Chem (Rus).- 1997.-Vol.33, N 3.-P.1257-1259 13 Martynov A.V., Smilanskaya M.V., Kozuch I.A., Volkovich O.O., Popova N.V., Kislichenko V.S. Anticancer effects of vegetable glicoproteins, that affinity to G-class immunoglobulins // Pharm. J.-2000.-N 5.-P.78-80 (Ukr) 14 Martynov A.V., Babkin M.V., Prochoriatova E.V., Smilanskaya M.V., Peremot S.D., Gadzevich D.V., Stecenko O.V., Volkova V.V., Rudenko M.V. 1,5-pipiredil-3,7-bis (dietanolamino) – pirimidilisovalerianat for viral infection diagnostics // Ukrainian Patent # 37622 A 15 Martyniv A.V., Smilanskaya M.V., Parchomenko A.A., Pamchenko L.A., Kuchma I.Yu., Chernych V.P., Schemchuk L.A. p-carbetoxyphenylaconitimid with antiviral properties toward vesicular stomatitis virus and herpes simplex virus // Ukrainian patent # 22189 A. 16 Smelyanskaya M.V., Prochoriatova E.V., Babkin V.F., Panchenko L.A., Volyansky A.Yu., Chodak L.A., Martynov A.V., Pochil S.I., Kuchma I.Yu., Lisnyak Yu.V. Method of viruses detection // Ukrainian patents # 23678 A. 17 Khaled A.Z., Zuravlev N.S., Martynov A.V. Studying of catechines and leucoantocyanidines of dock families for photodynamic anticancer activity // Pharmacom.-2002.-N 2-P.105-107 18 Martynov A.V., Kislichenko V.S., Tkachenko O.Yu., Vinnik O.V. Technological aspects of injectable Ribes Nigrum anticancer proteoglicans // News in pharmacy.- 2002.-N 1(29).- P.33-35 19 Martynov A.V., Chernych V.P. Synthesis and biological properties of immunoglobulins, acylated by succinia cnhydrides // News in pharmacy.- 2002.- N 3 (31).- P.13-16 20 Litvinenko V.I., Martynov A.V., Popova N.V., Kozuch I.A. Some technological and biopharmaceutical features of Bergenia lectines extraction // Pharmacom.- 2002.-N 3.- P.18-21 21 Martynov A.V., Chernych V.P. Drug-design and synthesis of antiviral substances – nuclear import signals inhibitors – from succinylated peptides group // News in pharmacy.- 2003.- N 1 (33).- P.3-6. 22 Martynov A.V. Synthesis and properties of succinylated polynucleotides // News in Pharm.- 2003.-N 2(34).- P.20-23 23 Martynov A.V., Chernych V.P. Synthesis and biological properties of vegetable proteins, succinic anhydride acylated // Drugs.-2003.-N 1-2, P.73-76 24 Martynov A.V., Chernych V.P. Synthesis and antiproliferative properties of succinylated and aconitylated derivatives of recombinant a-2b-interferons // Exp. Oncology. - 2003.- Vol. 25, N 4. – P. 52-54 25 Martynov A.V. Studying of structure – activity dependence in recombinant a-2-b- interferon succinylated derivatives // News in Pharm.-2003.-N 4 (36).-P.18-21 26 Martynov A.V., Chernyh V.P. Features of antiviral polyanionic biopolymers exuberant negative charge definitions in its structure analysis // News in Pharm.- 2004.- N 1(37).-P.3-6 27 Poteyko P.I., Martynov A.V., Smelyanskaya M.V., Peremot S.D., Kireev I.V. Experience of tuberculosis patients treatment with used anticytomegalovirus polyclonal immunoglobulins // Med. today and tomorrow.- 2003.-N 4.-P.88-91 28 Martynov A.V., Smelyanskaya M.V., Kuchma I.Yu., Chernych V.P., Parchomenco A.A. β-D-glucosammonium salt of α-bromisovaleric acid with antiviral activity for vesicular stomatitis virus, herpes simplex virus and coronavirus // Ukrainian Patent N 23352 А. 29 Smelyanskaya M.V., Martynov A.V. Features of used of new drug with antiviral activity – Alfavir for HCMV treatment // Vesn. Probl.of boil.and med. -1997.-Vol.14.- P.83-88 30 Peremot S.D., Smelyanskaya M.V., Martynov A.V. Toxoplasmosis laboratory diagnostics and criteria of it examination // Vesn. Probl.of boil.and med. -1998.-Vol.23.- P.65-68 31 Diky I.L., Martynov A.V. About question of target cancer therapy. Used of polyclonal immunoglobulins for chemeric affinotoxins receptions // Vesn. Probl.of boil.and med. -19998.-Vol.17.- P.101-107 32 Smelyanskaya M.V., Sanina E.V., Peremot S.D., Kuchma I.Yu., Martynov A.V. Clinical and laboratory aspects of mother – child infection at the present stage // Medical news .- 1998.-N 2.-P.10-12 33 Prochoriatova E.V., Bila N.V., Volkova V.V., Martynov A.V. Studying of infections laryngotracheitis virus and New-Castle Virus in ovo // Veterenary medicine .- 2000.-Vol.1, N 78.-P.251-255 34 Martynov A.V., Shmatko Yu.V., Smelyanskaya M.V., Peremot S.D., Vinnik Yu.M. Detection of herpes virus type 1 antigen in lymphocytes and tumor tissue of patients with cancer of uterus // Exp. Oncology. - 2002.- Vol. 24, N 2. – P.120-122 35 Martynov A.V., Volyanskaya N.P. Studying of alfavir medical effects in rabbits ophtalmogerpes model // Vesn. Vin. Derg.Med.Univ.-2002.- N 2.-P.311-313 36 Marashina T.A., Psechenko N.V., Osolodchenko T.P., Martynov A.V., Paranich A.V., Savchenko S.P. Pathogenic value of antioxidant homeostasis in mice with escherichiosis // Vesn. Probl.of boil.and med. -2002.-Vol.5.- P.17-21 37 Application for Ukrainian patent 98062886 03.06.1998 MKI 6 А 61 К 31/00, 6 С 12 N 7/00 / Method of ointment reception for treatment of diseases, caused by intracells infections // Martynov A.V., Smilanskaya M.V., Peremot S.D., Kuchma I.Yu., Volyansky A.Yu., Mizger T.G., Dgurovich R., Dobroscok O.I. 38 Application for Ukrainian patent 96124561 from 05.12.1996 MKI 6 А 61 К 31/16, С 07Н 5/06 // Aconitanilic acid glucosammonium salts with anticancer activity// Martynov A.V., Chernych V.P., Smilanskaya M.V., Volyansky A.Yu., Schemcuk L.A. 39 Application for Ukrainian patent 97105000 from 13.10.1997 MKI 6 А 61 К 35/14 // Methods of adoptive immunotherapy of cancer // Martynov A.V., Volyansky Yu.L., Dobroscok O.I., Kuchma I.Yu., Malcev V.I., Moskalenko V.F., Dgurovich R., Tarasov O.A. 40 Kuchma I.Yu., Volyansky A.Yu., Moskalenko V.F., Tkachuk T.B., Dobroskok A.I., Martynov A.V., Smelyanskaya M.V., Peremot S.D. Using of cis-aconitic acid phenylimides in liposomal form for herpes treatment // J. Micr.Epid.Immunobiol.-2000.- N 5.- P.58-61 41 Babich E.M., Kolokolova E.E., Volyansky Yu.L., Krasnopolsky Yu.M., Martynov A.V., Verezub L.G., Belozersky V.I., Sklyar N.I., Volyanskaya N.P. Studying of Bordetella Pertussis antigens liposomal form ajuvanticity with oral used // Exp. And clin.med.-2002.-N 3.-P.87-90 42 Martynov A.V. Analysis of the low effectiveness causes of modern treatment methods of cancer mal-formations // Ann. Mech. Inst.-2002.-N 2-3.- P.57-60 43 Method of tuberculosis patients treatment by anticytomegalovirus polyclonal immunoglobulins / Poteyko P.I., Martynov A.V., Smilyanskaya M.V., Chernyavsky V.I., Peremot S.D., Kuchma I.Yu., Bozko M.G., Nomerovchenko V.M. // MKI7 А61К39/00, А61К39/12, А61К39/390 Ukrainian patent N 63791 А from 63791 А, publ. . 15.01.2004., bull. N 1. 44 Litsmanova N.V., Martynov A.V., Paranitch A.V., Svich V.A., Marishina T.A. Stability ob lipide bilayer and it laser light modification // ХІV Int. Sc.-pract. Confer “Application of lasers in biology and medicine” 2000, may 16-19, Kharkov., P.8-9 45 Martynov A.V., Smelyanskaya M.V. Studying of autoadopting immunoliposomal system for selective targeting of drugs to cancer cells // Resp. Sc. Conf. “ Scientific directions in drug-design in Ukrainian pharmacy 2000, sept. 26-28 Kharkov.-P.61-62 46 Litsmsnova N., Paranich A., Martynov A., Marishina T. Stability of lipid bilayer in model systems and methods of its modification/ Eur. Bioph.J.-2000.- Vol.29, N 4-5.-P.293-294. 47 Martynov A.V., Volyanskaya N.P. Medical effect of alfavir for rabbit ophtalmoherpes treatment // Int. Sc.-Pract. Conf. “Actual questions of strategy and practical in used of antiseptics and antibiotics” 2002, sept. 11-12, Vinnitca. 48 Martynov A.V., Kuchma I.Yu. Transposones as a factors of viruses, microorganisms and cancer cells pathogenicity // Int. Sc.Conf “Strategy and tactics in struggle wits infectious diseases” Kharkov 2001. P.12. 49 Martynov A.V., Peremot S.D., Smelyanskaya M.V. Herpesviruses as a fector of immune reaction disbalance in cancer patients // Int. Sc.Conf. “Strategy and tactics of infectious diseases struggle” Kharkov, Oct. 23-24. 2001.-P.15-16 50 Popova N.V., Litvinenko V.I., Martynov A.V., Volkovich O.A. Helichrisum arenarium – perspective plant // Achievements of a modern pharmaceutics and prospect of its development in a new millennium. V national congress of Ukrainian pharmacist.-Kharkov, 1999.-P.322-333 51 Martynov A.V. Proteines and multiple protein ensemble acylation as a method for its biological activity increased // VII Int. Med.Congr. Stud. And young Sc. May 21-23, 2003.- P.256 52 Martynov A.V., Smilyanskaya M.V., Peremot S.D. Development of b-importin nuclear import signals inhibitors – succinylated peptides – for clear of cancer cells and immunocytes from persistence herpesviruses // Oncology -2003.- Vol.5 , N 2.- P.174-175 53 Smelyanskaya M.V., Peremot S.D., Kireev I.V., Samura B.B. Using of specific “Biopharma” immunoglobulin for antiviral immunorehabilitation of patients with herpesviral persistence // Ukr. Sc.-Pract. Conf. “Drugs for human”.18/12/2003.-Kharkov. P. 143-144 54 Smelyanskaya M.V., Martynov A.V., Peremot S.D. Substantiation of application of immunorehabilitation for patients with herpesviral persistence // Rus. Congress of doctors-infectionists.- 29-31.10.2003.- Sankt-Petersburg (Russia).- P.361 55 Fundamental research of antiviral and anticancer drugs with targeting properties. // Report of Sc.-Res. Work.// IMI.- CFFN 42498, Gov. reg. N 0198U002478.- Kharkov., 2001.- 94 P. 56 Development of anatoxins and somatic antigens immunifacient entheral forms for nonparentheral vaccines reception for diphtheria, meningococcus and pertussis prophylaxis // Report of Sc.-Res. Work.// IMI.- CF4.32.99, Gov. reg. N 0199U003173.- Kharkov.-2001.-142 P. 57 Development of immunorehabilitation methods for cancer patients with herpesviral persistence.// IMI.-АМS 41/2001; Gov. reg. N 0101U001117.- Kharkov., 2002.-112 p.
58 Martynov AV, Tymchenko OM, Pokhyl SI.
Chemically modified specific immunoglobulins for legionellosis
laboratory diagnostics 59 Мartynov А.V., Smelyanskaya M.V. Antiproliferative properties of chemically modified a-2b-recombinant interferon // J. of Interf. & Cytokine res.- 2005.-Vol. 25, N 7.- P. 414-417 (Engl) 60 Martynov A.V., Smelyanskaya M.V. , Peremot S.D., Sorochan P.P., Nikiforova N.A. Correlation between herpesviral persistence in immunocytes and condition of immune system in cancer patients // J. of AMSU. -2004.-10(2).- P.385-391 (Ukr) 61 Pshechenko, N., Paranich, A., Martynov, A., Svitch, V., Marishina, T Liposomes for the treatment of inoculation colibacteriosis of a mice // Euromedlab (Int.Congress).- 2001.- PO-B024 (http://www.congress.cls.cz/euromedlab2001/) (Engl) 62 Pshechenko, N., Paranich, A., Martynov, A., Svitch, V., Marishina, T. The using of perspective medicinal form – liposomes for the treatment of inoculation colibacteriosis of a mice // Euromedlab. (Int.Congress) - 2001.- PO-W037 (http://www.congress.cls.cz/euromedlab2001) (Engl) 63 Lisnyak Yu.V., Gubskaya A.V., Martynov A.V. b-Cyclodextrin inclusion complexes with methylxanthines. Molecular mechanics accounting for the solvent. // MACC-1, Kharkiv, 30 June- 1 July 2005. –P. 49 (Engl) 64 Martynov A.V. New approach to synthesis of trans-aconitic acid imides // RJOC.-2005.-41(5).- P. 731-734 65 Martynov A.V., Smelyanskaya M.V. , Peremot S.D., Sorochan P.P., Nikiforova N.A. Influence of herpesviral persistence in immunocytes on immune system of cancer patients // Modern infections.- 2004.-1.-P.25-30 66. Martynov A.V., Babych E.M., Smelyanskaya M.V. Increase of vaccines adjuvanticity by succinylation of vaccine antigen// Rejuvenation Research.- Aug 2005, Vol. 8, No. 1:P.14-17 67. Смелянская М.В., Перемот С.Д., Мартынов А.В. Персистирующие герпесвирусы как потенциальный тригер-фактор соматических заболеваний // Анн. Мечн. Инст.-2006.- № 4.-С.29-34 68. Білозерський В.І., Бабич Є.М., Волянський Ю.Л., Краснопольський Ю.М., Щетініна В.М., Колоколова О.Б., Верезуб Л.Г., Мартинов А.В., Ждамарова Л.А., Скляр Н.І., Чуєшов В.І. Експериментальні підходи до створення ентеральних форм протидифтерійних препаратів // Анн. Мечн. Инст.-2006.- № 4.-С.9-14 69. Чернявский В.И., Бирюкова С.В., Мартынов А.В., Смелянская М.В., Беляевская С.Ю., Перемот С.Д., Криворучко И.А., Романова М.В., Радченко А.А., Сейдаметов Р.Р. HELICOBACTER PYLORI-ERPESVIRIDAE ассоциации в этиопатогенезе неопластических поражений желудка. Современные аспекты изучения // Анн. Мечн. Инст.-2005.- № 3-4.-С.6-13 70. Чернявський В.І., Бірюкова С.В., Смелянська М.В., Перемот С.Д., Біляєвська С.Ю., Мартинов А.В., Крестецька С.Л. Серологічні маркери h.pylori та герпесвірусів у хворих на рак шлунку // Анн. Мечн. Инст.-2005.- № 1.-С.48-66 71. Городницька Н.І., Ясна Н.С., Мартинов А.В., Чернявський В.І., Козубова Г.М., Смілянська М.В., Осолодченко Т.П., Перемот С.Д., Романова О.А., Ігумнова Н.І., Сидоренко Т.А. Сучасний стан розробки хімічних вакцин для профілактики синьогнійної інфекції // Анн. Мечн. Инст.-2006.- № 3.-С.4-18 72. Ясна Н.С., Мартинов А.В. Порівняння ефективності фармакопейного біологічного методу встановлення активності (концентрації) ронколейкіну з імуноферментним і ВЕРХ – методами // Фармацевтичний журнал.- 2006.- № 1, С. 70-73 73. Ясна Н.С., Шевцов І.М., Мартинов А.В., Костіна Т.А., Кисличенко В.С. Методологічні особливості використання імунологічних серологічних методів для якісного та кількісного аналізу наднизької кількості високомолекулярних лікарських засобів в лікарських формах // Фармацевтичний журнал.- 2005.- № 6, С.54-59 74. Martynov AV, Tymchenko OM, Pokhyl SI. Effect of succinylation of Klebsiella 45 bacteriophage proteins on specific lytic activity. Mikrobiol Z. 2005 Sep-Oct;67(5):80-8. Ukrainian.
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